Research on Fibromyalgia:
Fibromyalgia: Complementary and alternative treatments
Rhodiola Rosea
A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
D-Ribose
The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.
Gut Health
Altered microbiome composition in individuals with fibromyalgia
A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls
The presence of metabolic indicators of perturbations in the gut microbiome (hippuric, 2-hydroxyisobutyric and lactic acids) supports the paradigm that regulation of the gut-brain axis becomes affected in stress related disorders, like FMS. Three metabolite markers (taurine, creatine and succinic acid) were important for the differentiation between FMS patients and controls and were significant indicators of the pain and fatigue symptoms in FMS
Free amino acids in fibromyalgia syndrome: relationship with clinical picture.
Serum leptin in Egyptian patients with fibromyalgia syndrome: relation to disease severity
Vitamin D
Serum vitamin D level and bone mineral density in premenopausal Egyptian women with fibromyalgia.
Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia.
Vitamin D and fibromyalgia: a meta-analysis.
The role of vitamin D testing and replacement in fibromyalgia: a systematic literature review
The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review
Purine metabolites in fibromyalgia syndrome
5-hydroxytryptophan (5-HTP)
Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.
5-Hydroxytryptophan: a clinically-effective serotonin precursor
S-adenosyl-L-methionine (SAMe)
Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation
Evaluation of S-adenosylmethionine in primary fibromyalgia. A double-blind crossover study.
Double-blind, placebo-controlled cross-over study of intravenous S-adenosyl-L-methionine in patients with fibromyalgia.
Omega-3 fatty acids
Complementary and Integrative Methods in Fibromyalgia
In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.
The ω3 fatty acids have mild anti-inflammatory properties, decreasing synthesis of thromboxane A2 from arachidonic acid. Intake of ω3 fatty acids is inversely associated with major depression, (43)(44) a strong comorbidity with chronic fatigue syndrome and fibromyalgia. (45) Furthermore, serum levels of the ω3 fatty acid eicosapentaenoic acid are significantly lower in patients with chronic fatigue syndrome than in healthy controls. (46) Supplementation with ω3 fatty acid has some evidence of efficacy in treating a number of nonspecific symptoms associated with fibromyalgia, including fatigue, arthralgias, (47) depression, (48) and anxiety. (49)
We suggest ω3 fatty acids as an initial recommendation, with 5-HTP and SAM-e as secondary choices. The ω3 fatty acids have more potential benefits in other areas related to chronic widespread pain and fibromyalgia, whereas 5-HTP and SAM-E essentially work as serotonergic antidepressants.
Omega-3 fatty acids for neuropathic pain: case series
Creatine
Creatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trial
These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients.
Acetyl-l-carnitine
Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients.
these results indicate that LAC may be of benefit in patients with FMS, providing improvement in pain as well as the general and mental health of these patients
A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: preliminary data.
these preliminary findings confirm the efficacy of duloxetine, and suggest that acetyl L-carnitine is also efficacious in improving depressive symptoms, pain, and the quality of life of FMS patients
Ashwagandha
An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda
There are dozens of studies that show that Ashwagandha slows, stops, reverses or removes neuritic atrophy and synaptic loss. Therefore Ashwagandha can be used to treat Alzheimer’s, Parkinson’s, Huntington’s and other neurodegenerative diseases at any stage of the disease, even before a person has been diagnosed and is still in the state of mild forgetfulness, etc.
NADH and CoQ10
Does Oral Coenzyme Q10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome?
Therefore, CoQ10 plus NADH as natural supplementation could be used as a possible alternative and complementary therapy for this condition and even in other chronic illnesses associated to fatigue.
Exercise
Prescribed exercise in people with fibromyalgia: parallel group randomised controlled trial
Magnesium
Is Fibromyalgia Due to a Mineral Deficiency?
Using supplemental magnesium to treat fibromyalgia symptoms
B12
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
B1 Thiamine
High-dose thiamine improves the symptoms of fibromyalgia